103-01v ScienCell 重組人腫瘤壞死因子-alpha,Variant rhTNF-α variant,Recombinant Human Tumor Necrosis Factor-alpha Variant
ScienCell 研究實驗室(ScienCell)是一家生物技術公司,其使命是實驗和治療用細胞和細胞相關產品的研究和發(fā)展。 ScienCell為研究界提供各種高質量的正常的人類和動物細胞,細胞培養(yǎng)基和試劑,培養(yǎng)基添加因子,細胞來源的RNA,cDNA和蛋白質。ScienCell的科學家們以改善生活質量,實現(xiàn)細胞的能力,打擊人類退化性疾病為目的研究和開發(fā)各種細胞治療策略。ScienCell總部設在美國加利福尼亞州圣地亞哥,公司成立于1999年。
北京諾博萊德作為ScienCell品牌的特約經(jīng)銷商,為客戶提供,正規(guī)進口,貨期穩(wěn)定,折扣好的服務標準。
103-01v ScienCell重組人腫瘤壞死因子-alpha,Variant rhTNF-α variant,Recombinant Human Tumor Necrosis Factor-alpha Variant,產品簡介:
產品品牌; ScienCell
產品貨號:103-01v
產品名稱:103-01v ScienCell重組人腫瘤壞死因子-alpha,Variant rhTNF-α variant,Recombinant Human Tumor Necrosis Factor-alpha Variant
產品規(guī)格:10ug
ScienCell提供純化的、高質量的生長因子,為您的研究助力。一些專門的信號分子,在細胞的增殖和分化中發(fā)揮核心作用。只有高純度的因子才能實現(xiàn)信號通路的高強度活化。 ScienCell提供的生長因子具有以下特性:高活性,少量的蛋白即有很強效應;高純度,污染物少,干擾小。
103-01v ScienCell重組人腫瘤壞死因子-alpha,Variant rhTNF-α variant,Recombinant Human Tumor Necrosis Factor-alpha Variant, 產品說明:
TNF-α的強效抗腫瘤活性的臨床應用受到促炎副作用的限制,包括發(fā)熱、劑量限制性低血壓、肝毒性、血管內血栓形成和出血。設計臨床適用的具有低全身毒性的TNF-α突變體一直是藥理學的強烈興趣。與小鼠TNF-α結合的小鼠TNF-相比,人TNF-α與小鼠TNF-α55結合但不與小鼠TNF-α75結合,在小鼠中表現(xiàn)出保留的抗腫瘤活性和降低的全身毒性?;谶@些結果,已經(jīng)設計了許多選擇性結合TNF-α55的TNF-α突變體。這些突變體在體外對腫瘤細胞系表現(xiàn)出細胞毒性活性,并且在體內表現(xiàn)出較低的全身毒性。
The clinical use of the potent antitumor activity of TNF-α has been limited by the proinflammatory side effects including fever, dose-limiting hypotension, hepatotoxicity, intravascular thrombosis, and hemorrhage. Designing clinically applicable TNF-α mutants with low systemic toxicity has been an intense pharmacological interest. Human TNF-α, which binds to the murine TNF-α55 but not to the murine TNF-α75, exhibits retained antitumor activity and reduced systemic toxicity in mice compared with murine TNF-α, which binds to both murine TNF receptors. Based on these results, many TNF-α mutants that selectively bind to TNF-α55 have been designed. These mutants displayed cytotoxic activities on tumor cell lines in vitro, and exhibited lower systemic toxicity in vivo.
ScienCell生長添加物產品訂購信息:
102-01 重組人干細胞因子 rhSCF,Recombinant Human Stem Cell Factor 2ug
102-02 重組人粒細胞集落刺激因子 rhG-CSF,Recombinant Human Granulocyte Colony Stimulating Factor 2ug
102-03 重組人粒細胞巨噬細胞集落刺激因子 rhM-CSF,Recombinant Human Granulocyte Macrophage Colony Stimulating Factor 5ug
102-09 重組人巨噬細胞集落刺激因子 rhM-CSF,Recombinant Human Macrophage Colony Stimulating Factor 2ug
103-01 重組人腫瘤壞死因子-alpha rhTNF-α,Recombinant Human Tumor Necrosis Factor-alpha 10ug
103-01H 重組人腫瘤壞死因子-alpha,rhTNF--His,Recombinant Human Tumor Necrosis Factor-alpha, His 10ug
103-01v 重組人腫瘤壞死因子-alpha,Variant rhTNF-α variant,Recombinant Human Tumor Necrosis Factor-alpha Variant 10ug
103-04 重組人B細胞激活因子 rhBAFF,Recombinant Human B Cell Activating Factor 5ug
103-08 重組人制瘤素-M227a.a. rhOSM,Recombinant Human Oncostatin-M 227a.a. 2ug
103-08T 重組人制瘤素-M209a.a.,Recombinant Human Oncostatin-M209a.a 2ug
103-09 重組人血管生成抑制因子K1-3 rhAngiostatin K1-3,Recombinant Human Angiostatin K1-3 10ug
103-12 重組人血管內皮抑制素 rhEndostatin,Recombinant Human Endostatin 20ug
104-01 重組人成纖維細胞生長因子-acidic rhaFGF,Recombinant Human Fibroblast Growth Factor-acidic 10ug
104-02 重組人成纖維細胞生長因子-basic rhbFGF,Recombinant Human Fibroblast Growth Factor-basic 10ug
104-07 重組人角質細胞生長因子 rhKGF-1,Recombinant Human Keratinocyte Growth Factor-1 2ug
104-09 重組人成纖維細胞生長因子-9 rhFGF-9,Recombinant Human Fibroblast Growth Factor-9 5ug
104-10 重組人角質細胞生長因子-2 rhKGF-2,Recombinant Human Keratinocyte Growth Factor-2 5ug
104-19 重組人成纖維細胞生長因子-19 rhFGF-19,Recombinant Human Fibroblast Growth Factor-19 5ug
104-21 重組人成纖維細胞生長因子-21 rhFGF-21,Recombinant Human Fibroblast Growth Factor-21 5ug
105-01 重組人胰島素生長因子-1 rhIGF-1,Recombinant Human IGF-I 20ug
105-01B 重組人DES(1-3)胰島素生長因子-1 rhIGF-BP3,Recombinant Human DES (1-3) IGF-1 20ug
105-01B3重組人胰島素生長因子-BP3,Recombinant Human IGF-BP3 5ug
105-03 重組人longR3胰島素生長因子-1 rhLR3IGF-1,Recombinant Human Long R3 Insulin-like Growth Factor-1 20ug
105-04 重組人表皮生長因子 rhEGF,Recombinant Human Epidermal Growth Factor, 100 ug 100ug
105-05 重組人血管內皮生長因子-165 rhVEGF165,Recombinant Human VEGF165 2ug
106-06 重組人干擾素γ rhIFN-γ,Recombinant Human Interferon-gamma 20ug
107-04 重組人神經(jīng)營養(yǎng)蛋白-4 rhNT-4,Recombinant Human Neurotrophin-4 2ug
107-08 重組人纖毛神經(jīng)營養(yǎng)因子 rhCNTF,Recombinant Human Ciliary Neurotrophic Factor 5ug
107-10 重組人神經(jīng)調節(jié)蛋白 rhBTC,Recombinant Human NRG-1 EGF-like domain 10ug
107-11 重組人ErbB3片段 rhErbB3-f,Recombinant Human ErbB3 Fragment 5ug
107-12 重組人β動物纖維 rhBTC,Recombinant Human Betacellulin 5ug
108-02 重組人骨形成蛋白-2 rhBMP-2,Recombinant Human Bone Morphogenetic Protein-2 2ug
108-04 重組人骨形成蛋白-4 rhBMP-4,Recombinant Human Bone Morphogenetic Protein-4 2ug
108-07 重組人骨形成蛋白-7 rhBMP-7,Recombinant Human Bone Morphogenetic Protein-7 2ug
108-08 重組人骨保護素 rHuOPG-Fc,Recombinant Human Osteoprotegerin/Fc Chimera 10ug
108-09 重組人NOGGIN蛋白 rhNOGGIN,Recombinant Human NOGGIN 5ug
301-01 重組人生長激素 rhGF,Recombinant Human Growth Hormone 20ug